A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.
Keywords: alkyl halides; bifunctionalization; chlorotrifluoromethylation; ruthenium catalysis; unactivated alkenes.
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