TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway

Dorothy Benton; Jonathan Chernoff

doi:10.1016/j.chembiol.2023.06.023

TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway

Cell Chem Biol. 2023 Jul 20;30(7):699-701. doi: 10.1016/j.chembiol.2023.06.023.

Authors

Dorothy Benton¹, Jonathan Chernoff²

Affiliations

¹ Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
² Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Electronic address: Jonathan.Chernoff@fccc.edu.

PMID: 37478825
DOI: 10.1016/j.chembiol.2023.06.023

Abstract

In this issue of Cell Chemical Biology, Liu et al.¹ identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Colonic Neoplasms*
Hippo Signaling Pathway
Humans
Protein Serine-Threonine Kinases* / metabolism
Serine-Threonine Kinase 3
Signal Transduction
Ubiquitination

Substances

Protein Serine-Threonine Kinases
Serine-Threonine Kinase 3