We propose a scheme to generate a single-photon source based on photon blockade in the Jaynes-Cummings (J-C) model with a two-photon dissipation (TPD) process. We present the optimal conditions for conventional/unconventional photon blockade via the wave function method with an effective Hamiltonian involving TPD. The results show that the second-order correlation function for the J-C model with TPD is considerably less than that of the J-C model with single-photon dissipation. Additionally, the average photon number can reach 0.5 in the large atomic detuning regime. This feature makes the J-C model with TPD a high-quality single photon source.