No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

J Clin Invest. 2023 Sep 1;133(17):e171742. doi: 10.1172/JCI171742.

Natalie E Stevens^{1

2}, Feargal J Ryan^{1

2}, Nicole L Messina^{3

4}, Stephen J Blake^{1

2}, Todd S Norton¹, Susie Germano³, Jane James¹, Georgina L Eden¹, Yee C Tee^{1

2}, Miriam A Lynn^{1

2}, Rochelle Botten¹, Simone E Barry⁵, Nigel Curtis^{3

4}, David J Lynn^{1

2}

¹ Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
² Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia, Australia.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
⁴ Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
⁵ Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

No abstract available

Keywords: COVID-19; Epigenetics; Innate immunity; Monocytes; Vaccines.

Publication types

Vaccine nonspecific effects of live and non-live vaccines: understanding the mechanisms and potential consequences (2022-2024).