Comparative Study Of Combined Co-Enzyme Q10 And Clomiphene Citrate Vs Clomiphene Citrate Alone For Ovulation Induction In Patients With Polycystic Ovarian Syndrome

J Pak Med Assoc. 2023 Jul;73(7):1502-1505. doi: 10.47391/JPMA.7299.

Abstract

A total of 136 patients with PCOS were followed through the Department of the Obstetrics and Gynaecology, Unit-IV, Lady Aitchison Hospital, Lahore. Patients were randomly divided by lottery method into two groups i.e., Group-A (CoQ10 plus Clomiphene citrate) and Group-B (Clomiphene citrate alone). The selected patients in the study group (group-A) were given Clomiphene citrate 100mg/day from cycle days 2-6 for 45 days (2 cycles) and CoQ10 in a dose of 50mg soft gel capsules thrice per day starting at cycle day-2, until HCG administration. Patients in controlled group (group 21 B) received Clomiphene citrate 100mg/day twice a day cycle for 45 days. Data were analysed in SPSS v25.0. In group-A (CoQ10 plus Clomiphene citrate), successful ovulation induction was noted in 16 (23.5%) patients, showing that with the addition of CoQ10, the chances of ovulation induction increased.

Keywords: Co-enzyme Q10, Clomiphene Citrate, Ovulation Induction, Polycystic Ovarian Syndrome.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Clomiphene / therapeutic use
  • Female
  • Fertility Agents, Female / therapeutic use
  • Humans
  • Infertility, Female* / drug therapy
  • Infertility, Female* / etiology
  • Ovulation Induction / methods
  • Polycystic Ovary Syndrome* / complications
  • Polycystic Ovary Syndrome* / drug therapy
  • Pregnancy
  • Ubiquinone / therapeutic use

Substances

  • coenzyme Q10
  • Clomiphene
  • Ubiquinone
  • Fertility Agents, Female