Metal-free electrochemistry promoted radical cascade cyclization to access CF3-containing benzimidazo[2,1- a]isoquinolin-6(5 H)-ones

Changjun Zhang; Zhichen Yu; Yuxin Ding; Yuan Shi; Yuanyuan Xie

doi:10.1039/d3ob00854a

Metal-free electrochemistry promoted radical cascade cyclization to access CF₃-containing benzimidazo[2,1- a]isoquinolin-6(5 H)-ones

Org Biomol Chem. 2023 Aug 23;21(33):6715-6718. doi: 10.1039/d3ob00854a.

Authors

Changjun Zhang¹, Zhichen Yu¹, Yuxin Ding¹, Yuan Shi¹, Yuanyuan Xie^{1

2

3}

Affiliations

¹ College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China. xyycz@zjut.edu.cn.
² Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China.
³ Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Hangzhou, 310014, China.

PMID: 37462425
DOI: 10.1039/d3ob00854a

Abstract

Using CF₃SO₂Na as the CF₃ radical source, an eco-friendly approach for electrochemistry-mediated radical cascade cyclization of N-methacryloyl-2-phenylbenzoimidazoles was described. This reaction features mild reaction conditions, readily available substrates, and moderate to good yields through the construction of two C-C bonds in one step.