Lipid in microglial biology - from material to mediator

Shota Yamamoto; Takahiro Masuda

doi:10.1186/s41232-023-00289-z

Lipid in microglial biology - from material to mediator

Inflamm Regen. 2023 Jul 17;43(1):38. doi: 10.1186/s41232-023-00289-z.

Authors

Shota Yamamoto¹, Takahiro Masuda²

Affiliations

¹ Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan. shota.yamamoto@bioreg.kyushu-u.ac.jp.
² Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan. takahiro.masuda@bioreg.kyushu-u.ac.jp.

Abstract

Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.

Keywords: CNS; Lipid; Macrophage; Microglia.

Publication types

Review