Analysis of ATG4C function in vivo

Autophagy. 2023 Nov;19(11):2912-2933. doi: 10.1080/15548627.2023.2234799. Epub 2023 Jul 17.

Abstract

ATG4 (autophagy related 4 cysteine peptidase); ATG4A (autophagy related 4A cysteine peptidase); ATG4B (autophagy related 4B cysteine peptidase); ATG4C (autophagy related 4C cysteine peptidase); ATG4D (autophagy related 4D cysteine peptidase); Atg8 (autophagy related 8); GABARAP (GABA type A receptor-associated protein); GABARAPL1(GABA type A receptor-associated protein like 1); GABARAPL2 (GABA type A receptor-associated protein like 2); MAP1LC3A/LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B/LC3B (microtubule associated protein 1 light chain 3 beta); mATG8 (mammalian Atg8); PE (phosphatidylethanolamine); PS (phosphatydylserine); SQSTM1/p62 (sequestosome 1).

Keywords: Animal models; GABARAP; LC3; autophagy; fibrosarcoma; lymphocyte.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Autophagy-Related Proteins* / metabolism
  • Cysteine
  • Mammals / metabolism
  • Mice
  • Microtubule-Associated Proteins / metabolism
  • gamma-Aminobutyric Acid

Substances

  • Autophagy-Related Proteins
  • Cysteine
  • gamma-Aminobutyric Acid
  • Microtubule-Associated Proteins
  • Atg4C protein, mouse

Grants and funding

This work was supported by grants from Ministerio Ciencia eInnovación (Spain) (PID2021-127534OB-I00), the South-Eastern 1315 Norway Regional Health Authority (2021088 to N.E.) and Instituto de Salud Carlos III (RTICC Spain). Jesús Prieto-Lloret is funded by Programa Estrategico IBGM, Escalera de Excelencia, ref. CCVC8485, Consejería de Educación, Junta de Castilla y León (Spain). Funding for open Access Charge: Roche Farma”, as the aricle will be published via Open access and the OA costs will be funded by Roche Farma.