Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective

Priyanka Verma; Ashok Chandak; Suyog Sharad Shetye; Aamir K Nazar; Swati Dinesh Bagul; Gaurav Malhotra

doi:10.4103/ijnm.ijnm_186_22

Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective

Indian J Nucl Med. 2023 Apr-Jun;38(2):183-184. doi: 10.4103/ijnm.ijnm_186_22. Epub 2023 Jun 8.

Authors

Priyanka Verma^{1

2}, Ashok Chandak¹, Suyog Sharad Shetye³, Aamir K Nazar¹, Swati Dinesh Bagul¹, Gaurav Malhotra^{1

2}

Affiliations

¹ Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
² Clinical Nuclear Medicine, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
³ Department of Surgery, Seth G S Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Abstract

A 53-year-old female, with a known case of adrenocortical carcinoma (ACC), underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for initial staging, which revealed FDG avid large left suprarenal mass contiguous with hypermetabolic tumor thrombus in the inferior vena cava (IVC) through the left renal vein. Thereafter, she underwent angiogenesis imaging using Ga-68-NODAGA-RGD PET/CT, which showed similar avid tracer uptake in both primary and IVC thrombus. Demonstration of RGD avidity in ACC in this case opens a new horizon for targeted radionuclide therapy (e.g., Lu-177 RGD) in selected patients, who may have limited therapeutic options.

Keywords: Adrenocortical carcinoma; F-18 fluorodeoxyglucose positron emission tomography/computed tomography; Ga-68-NODAGA-RGD positron emission tomography/computed tomography; Lu-177 RGD.