Atrial natriuretic peptide and leptin interactions in healthy men

Martin A Daniels; Pamela Fischer-Posovszky; Michael Boschmann; Reiner Jumpertz-von Schwartzenberg; Timo D Müller; Leontine Sandforth; Sabine Frank-Podlech; Sonja Hülskämper; Andreas Peter; Martin Wabitsch; Jens Jordan; Andreas L Birkenfeld

doi:10.3389/fendo.2023.1195677

Atrial natriuretic peptide and leptin interactions in healthy men

Front Endocrinol (Lausanne). 2023 Jun 30:14:1195677. doi: 10.3389/fendo.2023.1195677. eCollection 2023.

Authors

Martin A Daniels^{1

2

3

4}, Pamela Fischer-Posovszky^{5

6}, Michael Boschmann^{7

8}, Reiner Jumpertz-von Schwartzenberg^{1

2

3}, Timo D Müller^{1

9}, Leontine Sandforth^{1

2

3}, Sabine Frank-Podlech^{1

2}, Sonja Hülskämper^{1

2}, Andreas Peter^{1

2

10}, Martin Wabitsch^{5

6}, Jens Jordan^{11

12}, Andreas L Birkenfeld^{1

2

3

13}

Affiliations

¹ German Center for Diabetes Research (DZD e. V.), Neuherberg, Germany.
² Institute of Diabetes Research and Metabolic Disease (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany.
³ Department of Internal Medicine IV, Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Tübingen, Germany.
⁴ Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany.
⁵ Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
⁶ Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Center Ulm, Ulm, Germany.
⁷ Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Berlin, Germany.
⁸ Berlin Institute of Health, Berlin, Germany.
⁹ Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
¹⁰ Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, Tübingen, Germany.
¹¹ Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
¹² Chair of Aerospace Medicine, Medical Faculty, University of Cologne, Cologne, Germany.
¹³ Department of Diabetes, Life Sciences & Medicine Cardiovascular Medicine & Sciences, Kings College London, London, United Kingdom.

Abstract

Introduction: Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipokines. We tested the hypothesis that ANP lowers concentrations of the anorexigenic adipokine leptin in healthy humans in vivo.

Methods: Human ANP or matching placebo was infused intravenously (iv) into healthy men in a controlled clinical trial.

Results: Within 135 minutes of iv ANP infusion, we observed an acute decrease in plasma leptin levels compared to controls. Free fatty acids markedly increased with ANP infusion in vivo, indicating activated lipolysis. In human SGBS adipocytes, ANP suppressed leptin release.

Discussion: The study shows that the cardiac hormone ANP reduces the levels of the anorexigenic adipokine leptin in healthy humans, providing further support for ANP as a cardiomyokine in a heart - adipose tissue axis. (registered in the German Clinical Trials Register and the WHO International Clinical Trials Registry Platform was granted under DRKS00024559).

Keywords: ANP; atrial natriuretic peptide; heart failure; insulin resistance; leptin; lipolysis; obesity.

Publication types

Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes / metabolism
Adipose Tissue / metabolism
Atrial Natriuretic Factor* / metabolism
Atrial Natriuretic Factor* / pharmacology
Humans
Leptin* / metabolism
Lipolysis
Male

Substances

Atrial Natriuretic Factor
Leptin

Grants and funding

TM received research support from the German Research Foundation (DFG-TRR152 and TRR296). PF-P was supported by the Deutsche Forschungsgemeinschaft – Projektnummer 398707781 – Heisenberg professorship. AB received research support from the German Research Foundation (BI1292/10-1, BI1292/9-1, BI1229/12-1, GRK 2816). This work was funded in part by the German Center for Diabetes Research (DZD, 01GI0925). RJvS receives support from the Helmholtz Association by a Helmholtz Young Investigator Group.