Long-term chronic food-derived arsenic exposure induce the urinary system metabolic dysfunction in mice

Zhongjia Huang; Lianxian Guo; Xu Chen; Jiadi Sun; Yongli Ye; Lina Sheng; Yinzhi Zhang; Jianzhong Zhou; Jian Ji; Xiulan Sun

doi:10.1016/j.scitotenv.2023.165499

Long-term chronic food-derived arsenic exposure induce the urinary system metabolic dysfunction in mice

Sci Total Environ. 2023 Nov 10:898:165499. doi: 10.1016/j.scitotenv.2023.165499. Epub 2023 Jul 14.

Authors

Zhongjia Huang¹, Lianxian Guo², Xu Chen², Jiadi Sun¹, Yongli Ye¹, Lina Sheng¹, Yinzhi Zhang¹, Jianzhong Zhou³, Jian Ji⁴, Xiulan Sun⁵

Affiliations

¹ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, PR China.
² Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China.
³ College of Food Science and Pharmacy, Xinjiang Agricultural University, No. 311 Nongda Dong Road, Ürümqi, 830052, Xinjiang ygur Autonomous Region, PR China.
⁴ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, PR China; College of Food Science and Pharmacy, Xinjiang Agricultural University, No. 311 Nongda Dong Road, Ürümqi, 830052, Xinjiang ygur Autonomous Region, PR China. Electronic address: jijian@jiangnan.edu.cn.
⁵ State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, PR China; Yixing Institute of Food and Biotechnology, No. 19, Wenzhuang Road, Qiting Street, Yixing City, Wuxi, China.

PMID: 37454865
DOI: 10.1016/j.scitotenv.2023.165499

Abstract

The consumption of rice contaminated with arsenic on a long-term basis has emerged as a pressing public health issue of global significance. Arsenic-induced urinary injury, particularly kidney damage, has received widespread attention. In this study, mice model under long-term arsenic exposure was established, mouse were exposed to rice arsenic (30 mg/kg) for 14 months. Changes of related metabolites were observed based on kidney metabolomics and lipidomics, and major biomarkers were screened by urine metabolomics. The results showed that phosphatidylethanolamine (PE) was significantly increased and phosphatidycholine (PC) and phosphatidylglycerol (PG) were significantly reduced after arsenic exposure, leading to related downstream lipid metabolism disorders. The metabolic pathways for amino acid and energy were observed to be impacted. In addition, metabolic disorders due to arsenic exposure may be associated with inherited neurometabolic disorders, such as D-2-hydroxyglutaric aciduria (D-2-HGA), and pyruvate carboxylase deficiency (PCD), which is predicted based on significant difference biomarkers (2-oxoglutarate, malic acid, and succinic acid) screened for urine. This study elucidates the mechanism of toxicity in the urinary system induced by arsenic exposure at nearly half life cycle, which furnishes crucial scientific evidence pertaining to the toxicity and risk evaluation associated with chronic exposure to the arsenic.

Keywords: Arsenic; Lipidomics; Long-term exposure; Metabolomics; Urinary system.