The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis

Kai Sun; Jiachao Guo; Zhou Guo; Liangcai Hou; Haigang Liu; Yanjun Hou; Junchen He; Fengjing Guo; Yaping Ye

doi:10.1016/j.arr.2023.102015

The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis

Ageing Res Rev. 2023 Sep:90:102015. doi: 10.1016/j.arr.2023.102015. Epub 2023 Jul 14.

Authors

Kai Sun¹, Jiachao Guo², Zhou Guo¹, Liangcai Hou¹, Haigang Liu¹, Yanjun Hou¹, Junchen He¹, Fengjing Guo³, Yaping Ye⁴

Affiliations

¹ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
² Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
³ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: guofjdoc@163.com.
⁴ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: yyportho@163.com.

PMID: 37454824
DOI: 10.1016/j.arr.2023.102015

Abstract

Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The pathogenesis of OA is complicated and the current therapeutic approaches for OA are limited. Cartilage, an integral part of the skeletal system composed of chondrocytes, is essential for skeletal development, tissue patterning, and maintaining the normal activity of joints. The development, homeostasis and degeneration of cartilage are tightly associated with OA. Over the past decade, accumulating evidence indicates that Hippo/YAP is a vital biochemical signalling pathway that strictly governs tissue development and homeostasis. The joint tissues, especially for cartilage, are sensitive to changes of Hippo/YAP signalling. In this review, we summarize the role of Hippo/YAP signalling in cartilage and discuss its involvement in OA progression from points of cartilage degradation, subchondral bone remodeling, and synovial alteration. We also highlight the potential therapeutic implications of Hippo/YAP signalling and further discuss current limitations and controversy on Hippo/YAP-based application for OA treatment.

Keywords: Cartilage; Hippo; Osteoarthritis; TAZ; YAP.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cartilage / metabolism
Cartilage, Articular* / metabolism
Chondrocytes / metabolism
Humans
Osteoarthritis* / metabolism
Signal Transduction