Oriented ascorbic acid onto zeolitic metal-organic framework-8 membrane via microfluidic spinning for biomedical care

Abstract

Nowadays, the hydrogen dressing and electrostatic spun films widely used on wounds do not facilitate the permeability of the wound area and fail to achieve controlled drug delivery. Therefore, finding a wound dressing with both breathability and targeted drug delivery has remained an unmet challenge. Here, an oriented microstructure membrane with sustained drug release and robust antibacterial performance was constructed through the microfluidic spinning method. The multifunctional oriented membrane was prepared by loading ascorbic acid onto the zeolitic metal-organic framework-8 to develop drug delivery nanomaterial zeolitic metal-organic framework-8 @ascorbic acid (ZIF-8 @AA) and then mixing ZIF-8 @AA with polyvinyl pyrrolidone (PVP) solution via microfluidic technology, which produced an oriented microfiber member. In addition, the spinning parameters, including the fluid content, rotation speed, and flow rate, on microfiber diameter were evaluated. The constructed oriented membrane had bactericidal efficiencies of 82.94% ± 2.79% and 95.96% ± 1.54% against E. coli and S. aureus, respectively. After five days, the membrane still has a sustained release. Moreover, the fabricated membrane also has good biocompatibility and hemocompatibility in vitro. The oriented arrangement strategy provides a promising approach for wound healing materials in targeted drug delivery. Furthermore, this strategy offers a feasible idea for loading active materials into substrates for disease treatment in the biomedical field.

Keywords: Anti-bacteria; Biocompatibility; Drug-delivery; Microfluidic-spinning membrane; Zeolitic metal-organic framework-8.