Endocrine manifestations of COVID-19 in children: A scoping review

Sumudu Nimali Seneviratne; Chamathni Narmada Kumarihamy Karunathilake; Chamathka Madushi Pallegama; Thalompita Gamaralalage Malintha Lahiru; Umesh Jayarajah

doi:10.1016/j.beem.2023.101792

Endocrine manifestations of COVID-19 in children: A scoping review

Best Pract Res Clin Endocrinol Metab. 2023 Jul;37(4):101792. doi: 10.1016/j.beem.2023.101792. Epub 2023 Jun 28.

Authors

Sumudu Nimali Seneviratne¹, Chamathni Narmada Kumarihamy Karunathilake², Chamathka Madushi Pallegama³, Thalompita Gamaralalage Malintha Lahiru⁴, Umesh Jayarajah⁵

Affiliations

¹ Department of Paediatrics, Faculty of Medicine, University of Colombo, Sri Lanka. Electronic address: sumudu@pdt.cmb.ac.lk.
² Faculty of Medicine, University of Colombo, Sri Lanka. Electronic address: narmada95devi@gmail.com.
³ Faculty of Medicine, University of Colombo, Sri Lanka. Electronic address: pallegama.cm@gmail.com.
⁴ Lady Ridgeway Hospital for Children, Sri Lanka. Electronic address: malinthalahiru@gmail.com.
⁵ Postgraduate Institute of Medicine, University of Colombo, Sri Lanka; Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka. Electronic address: umeshe.jaya@gmail.com.

Abstract

In this review, we explore associations between SARS CoV-2 infection and the endocrine system and metabolism in children and adolescents. PubMed, Scopus and Google scholar databases were searched to identify published data on endocrine manifestations of COVID-19 in children up to 31 March 2023, including diabetes, obesity, puberty, thyroid disorders, adrenal disorders and pituitary disorders. Data on changes in disease pattern/ incidence, disease control, and other effects due to the COVID-19 pandemic, as well as effects of pre-existing endocrine conditions on severity of COVID-19 infection are presented, and practice points and research needs provided under each section.

Keywords: Coronavirus disease 2019; adolescents; children; diabetes; diabetic ketoacidosis; endocrine disorders; precocious puberty; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Publication types

Review

MeSH terms

Adolescent
COVID-19* / complications
Child
Diabetes Mellitus*
Endocrine System
Humans
Pandemics
SARS-CoV-2