Advances of exosomes-based applications in diagnostic biomarkers for dental disease and dental regeneration

Ziquan Lv; Kai Fu; Qian Zhang

doi:10.1016/j.colsurfb.2023.113429

Advances of exosomes-based applications in diagnostic biomarkers for dental disease and dental regeneration

Colloids Surf B Biointerfaces. 2023 Sep:229:113429. doi: 10.1016/j.colsurfb.2023.113429. Epub 2023 Jun 25.

Authors

Ziquan Lv¹, Kai Fu², Qian Zhang³

Affiliations

¹ Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
² Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
³ Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address: qianzhang@cau.edu.cn.

PMID: 37451223
DOI: 10.1016/j.colsurfb.2023.113429

Abstract

Exosomes are produced by all the cells and exist in all body fluids. They have been regarded as potentially promising to diagnostic biomarkers and therapeutic bioactive mediators since they transport DNA, RNA and protein information from cell to cell. Herein, we summarized the recent research about exosomes from gingival crevicular fluid, saliva and serum used as diagnostic markers in periodontitis and dental caries. Moreover, we highlighted the mechanisms of exosomes in dental pulp regeneration and periodontal regeneration, as well as the technological innovation of exosome delivery methods in oral disease. In the end, this review discussed the advantages and future challenges of exosomes in real clinical applications.

Keywords: Biomarker; Dental pulp; Exosomes; Periodontitis; Regeneration.

Publication types

Review

MeSH terms

Biomarkers
Dental Caries*
Dental Pulp
Exosomes*
Humans
Regeneration

Substances

Biomarkers