Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy

Yingying Shao; Yu Wang; Ranran Su; Weiling Pu; Sibao Chen; Leilei Fu; Haiyang Yu; Yuling Qiu

doi:10.1016/j.heliyon.2023.e17582

Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy

Heliyon. 2023 Jun 26;9(7):e17582. doi: 10.1016/j.heliyon.2023.e17582. eCollection 2023 Jul.

Authors

Yingying Shao^{1

2}, Yu Wang^{1

2}, Ranran Su^{1

2}, Weiling Pu^{1

2}, Sibao Chen^{3

4}, Leilei Fu⁵, Haiyang Yu^{1

2}, Yuling Qiu⁶

Affiliations

¹ Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
² Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
³ State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen, China.
⁴ Department of Applied Biology and Chemical Technology, Research Center for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China.
⁵ School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.
⁶ School of Pharmacy, Tianjin Medical University, Tianjin, China.

Abstract

Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity of tumors with different functional characteristics. Macrophages are now a central drug target in various diseases, especially in the TME, which, as "tumor promoters" and "immunosuppressors", have different responsibilities during tumor development and accompany by significant dynamic alterations in various subpopulations. Remodelling immunosuppression of TME and promotion of pre-existing antitumor immune responses is critical by altering TAM polarization, which is relevant to the efficacy of immunotherapy, and uncovering the exact mechanism of action of TAMs and identifying their specific targets is vital to optimizing current immunotherapies. Hence, this review aims to reveal the triadic interactions of macrophages with programmed death and oncotherapy, and to integrate certain relationships in cancer treatment.

Keywords: Cancer therapy; Drug delivery; Regulated cell death (RCD); Tumor microenvironment (TME); Tumor-associated macrophage (TAM).

Publication types

Review