Fe3O4@ABA-aniline-CuI nanocomposite as a highly efficient and reusable nanocatalyst for the synthesis of benzothiazole-sulfide aryls and heteroaryls

Abstract

Studying diaryl sulfides and benzothiazoles is important in organic synthesis because numerous natural and medicinal products contain these scaffolds. Over the past few years, research on the synthesis of compounds containing benzothiazole-sulfide aryls, as important biological molecules, has received significant attention. Multicomponent reactions are the most popular strategy for performing difficult reactions and the synthesis of complexed molecules such as benzothiazole-sulfide aryls. In this work, CuI was successfully immobilized on the surface of magnetic Fe₃O₄ nanoparticles modified with aniline and 4-aminobenzoic acid [Fe₃O₄@ABA-Aniline-CuI nanocomposite] and its catalytic activity was investigated in the preparation of a broad range of benzothiazole-sulfide aryls and heteroaryls through the one-pot three-component reactions of 2-iodoaniline with carbon disulfide and aryl or heteroaryl iodides in the presence of KOAc as base in PEG-400 as solvent. TEM and SEM images revealed that the shape of the Fe₃O₄@ABA-Aniline-CuI particles is spherical and the size of the particles is approximately between 12-25 nanometers.