Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide

Chengyi Liu; Guicai Du; Qunqun Guo; Ronggui Li; Changming Li; Hongwei He

doi:10.3390/nano13132000

Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide

Nanomaterials (Basel). 2023 Jul 3;13(13):2000. doi: 10.3390/nano13132000.

Authors

Chengyi Liu¹, Guicai Du¹, Qunqun Guo¹, Ronggui Li¹, Changming Li², Hongwei He³

Affiliations

¹ College of Life Sciences, Qingdao University, Qingdao 266071, China.
² Schneider Institute of Industrial Technology, School of Automation, Qingdao University, Qingdao 266071, China.
³ Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing, Qingdao University, Qingdao 266071, China.

Abstract

Polylactic acid (PLA) is a biodegradable polymer made from natural sources, and its electrospinning (e-spinning) nanofiber membrane doped with antibacterial ingredients is widely used in the field of medical dressings. In this research, 9 wt% of rosmarinic acid (RosA) and 0.04 wt% of graphite oxide (GO) with synergistic antibacterial activity were introduced into the e-spinning PLA precursor solution, and the obtained PLA nanofiber membrane showed good antibacterial properties and wound healing effects. At the same time, a nonionic amphiphilic polymer, polyethylene glycol (PEG), was also introduced into this system to improve the hydrophilicity of the e-spinning membrane for wound healing application. The morphological characterization showed the RosA/GO and PEG did not affect the e-spinning of PLA. The tests of mechanical performance and wettability demonstrated that PEG and RosA/GO incorporated in PLA have migrated easily to the surface of the fiber. The e-spun PLA/PEG/RosA/GO membrane showed good antibacterial activity and promoted initial wound healing quickly, which would be a promising application in wound dressing.

Keywords: PLA nanofiber; electrospinning; rosmarinic acid; wound healing.

Grants and funding

This work was supported financially by Natural Science Foundation of Shandong Province, China (ZR2020MC123) and Major R&D Projects in Shandong Province, China (2019JZZY020220).