Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study

Rodrigo Pessôa; Daniela Raguer Valadão de Souza; Youko Nukui; Juliana Pereira; Lorena Abreu Fernandes; Rosa Nascimento Marcusso; Augusto César Penalva de Oliveira; Jorge Casseb; Alberto José da Silva Duarte; Sabri Saeed Sanabani

doi:10.3390/ijms241310643

Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study

Int J Mol Sci. 2023 Jun 26;24(13):10643. doi: 10.3390/ijms241310643.

Affiliations

¹ Postgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.
² Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
³ Department of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.
⁴ Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
⁵ Laboratory of Medical Investigation Unit 03, Clinics Hospital, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
⁶ Laboratory of Dermatology and Immunodeficiency, LIM56/03, Instituto de Medicina Tropical de São Paulo Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 3° andar, São Paulo 05403-000, Brazil.

Abstract

Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.

Keywords: ATLL; HTLV-1; massive parallel sequencing; small RNA.

Publication types

Case Reports

MeSH terms

Adult
Female
Human T-lymphotropic virus 1* / genetics
Humans
Leukemia-Lymphoma, Adult T-Cell* / diagnosis
Leukemia-Lymphoma, Adult T-Cell* / genetics
Leukemia-Lymphoma, Adult T-Cell* / pathology
Lymphoma* / complications
RNA

Substances

RNA

Grants and funding

This work was supported by grant 2022/09354-9 from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).