Zinc (Ⅱ) functionalized magnetic geopolymer as sorbents for rapid extraction of Fluoroquinolones in food prior to quantification by UHPLC-MS/MS

Yang Song; Minli Yang; Feng Zhang; Meixia Xu; Xuesong Feng

doi:10.1016/j.foodchem.2023.136750

Zinc (Ⅱ) functionalized magnetic geopolymer as sorbents for rapid extraction of Fluoroquinolones in food prior to quantification by UHPLC-MS/MS

Food Chem. 2023 Dec 1:428:136750. doi: 10.1016/j.foodchem.2023.136750. Epub 2023 Jun 29.

Authors

Yang Song¹, Minli Yang², Feng Zhang³, Meixia Xu², Xuesong Feng⁴

Affiliations

¹ Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China; Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 100176, China; School of Phamacy, China Medical University, Shenyang, 110122, Liaoning, China.
² Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China; Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 100176, China.
³ Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China; Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 100176, China. Electronic address: fengzhang@126.com.
⁴ School of Phamacy, China Medical University, Shenyang, 110122, Liaoning, China.

PMID: 37441936
DOI: 10.1016/j.foodchem.2023.136750

Abstract

A novel Zn@MGeo sorbent was easily constructed and can bind with FQs through the synergistic effect of electrostatic interaction and coordination. With the Zn@MGeo as sorbent, a MSPE-UHPLC-MS/MS method was established for simultaneous detection of FQs in complex matrices. The whole extraction process could be completed using 6.0 mg sorbent within 10 min under the optimal conditions. The established quantitative method obtained a wide linear range (0.01-200 μg/kg, R² > 0.9987), high sensitivity (LODs: 0.005-0.05 μg/kg) and negligible matrix effect. The method was applied for analysis of real samples, with recoveries between 75.6% and 103.7%. In addition, the sorbent could be reused at least 9 times without reducing the adsorption performance. In general, the established method not only proposes a novel sorbent for FQs extraction, but also provides a powerful tool for rapid and sensitive detection of FQs in food matrices with practical application value.

Keywords: Fluoroquinolones; Food matrices; Geopolymer; Immobilized metal ion affinity chromatography; Magnetic solid phase extraction; UHPLC-MS/MS.

MeSH terms

Chromatography, High Pressure Liquid / methods
Fluoroquinolones* / analysis
Magnetic Phenomena
Solid Phase Extraction / methods
Tandem Mass Spectrometry* / methods
Zinc

Substances

Fluoroquinolones
Zinc