Recent advances in CD8+ T cell-based immune therapies for HIV cure

Valentina Restrepo Arenas; María T Rugeles; Federico Perdomo-Celis; Natalia Taborda

doi:10.1016/j.heliyon.2023.e17481

Recent advances in CD8⁺ T cell-based immune therapies for HIV cure

Heliyon. 2023 Jun 20;9(6):e17481. doi: 10.1016/j.heliyon.2023.e17481. eCollection 2023 Jun.

Authors

Valentina Restrepo Arenas¹, María T Rugeles¹, Federico Perdomo-Celis², Natalia Taborda^{1

3}

Affiliations

¹ Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.
² Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia.
³ Grupo de Investigaciones Biomédicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellin, Colombia.

Abstract

Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8⁺ T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8⁺ T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies.

Keywords: CD8+ T cells; Cure; HIV; Immunotherapy; Remission.

Publication types

Review