The rising prevalence of metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM) poses a major challenge to global health. Existing therapeutic approaches have limitations, and there is a need for new, safe, and less invasive treatments. Interventional metabolic therapy is a new addition to the treatment arsenal for metabolic disorders. This review focuses on two interventional techniques: bariatric arterial embolization (BAE) and endovascular denervation (EDN). BAE involves embolizing specific arteries feeding ghrelin-producing cells to suppress appetite and promote weight loss. EDN targets nerves that regulate metabolic organs to improve glycemic control in T2DM patients. We describe the current state of these techniques, their mechanisms of action, and the available safety and effectiveness data. We also propose a new territory called "Interventional Metabology" to encompass these and other interventional approaches to treating metabolic disorders.
肥胖和2型糖尿病(T2DM)等代谢性疾病的患病率不断上升给全球健康带来了重大挑战。现有的治疗方法有局限性, 我们需要新的、安全的、创伤较小的治疗方法。代谢性疾病的介入治疗是一种新的治疗手段。本文主要对两种介入技术:减重动脉栓塞术(BAE)和血管内去神经术(EDN)进行综述。BAE通过栓塞特定的动脉造成胃饥饿素下降, 从而抑制食欲和促进体重减轻。EDN靶向调节代谢器官的神经, 改善T2DM患者的血糖控制。我们描述了这些技术的现状、作用机制以及可用的安全性和有效性数据。我们还提出了一个新的领域, 称为“介入性代谢学”, 以涵盖这些和其他介入性治疗代谢性疾病的方法。.
Keywords: 2型糖尿病; T2DM; intervention metabology; metabolic disorders; obesity; 代谢干预; 代谢紊乱; 肥胖.
© 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.