Comparison between B-Scan and En Face Images for Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy

Federico Corvi; Giulia Corradetti; Rita Laiginhas; Jeremy Liu; Giovanni Gregori; Philip J Rosenfeld; Srinivas R Sadda

doi:10.1016/j.oret.2023.07.003

Comparison between B-Scan and En Face Images for Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy

Ophthalmol Retina. 2023 Nov;7(11):999-1009. doi: 10.1016/j.oret.2023.07.003. Epub 2023 Jul 10.

Authors

Federico Corvi¹, Giulia Corradetti², Rita Laiginhas³, Jeremy Liu⁴, Giovanni Gregori⁴, Philip J Rosenfeld⁴, Srinivas R Sadda⁵

Affiliations

¹ Doheny Eye Institute, University of California at Los Angeles, Los Angeles, California; Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy.
² Doheny Eye Institute, University of California at Los Angeles, Los Angeles, California; Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
³ Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal. Centro Hospitalar e Universitário São João, Porto, Portugal; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
⁴ Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
⁵ Doheny Eye Institute, University of California at Los Angeles, Los Angeles, California; Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California. Electronic address: ssadda@doheny.org.

PMID: 37437713
DOI: 10.1016/j.oret.2023.07.003

Abstract

Purpose: To evaluate and compare the detection of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete retinal pigment epithelium and outer retinal atrophy (cRORA) assessed on OCT B-scans versus persistent choroidal hypertransmission defects (hyperTDs) assessed by en face choroidal OCT images.

Design: Retrospective, cross-sectional study.

Participants: Patients with late atrophic age-related macular degeneration imaged on the same day using both Spectralis OCT and Cirrus OCT.

Main outcome measure: Agreement between the B-scan and en face OCT for the detection of hyperTDs, cRORA, and iRORA.

Methods: Two independent graders examined en face OCT and structural OCT to determine the presence and location of hyperTDs, iRORA, and cRORA.

Results: A total of 239 iRORA and cRORA lesions were detected on the B-scans, and 249 hyperTD lesions were identified on the en face OCT images. There was no significant difference (P = 0.88) in the number of lesions. There was no significant difference in the 134 cRORA lesions identified on B-scans and the 131 hyperTDs detected on en face OCT images (P = 0.13). A total of 105 iRORA lesions were identified by B-scan assessment; however, 50 of these iRORA lesions met the criteria for persistent hyperTDs on en face OCT images (P < 0.001). When considering the topographic correspondence between B-scan and en face OCT detected lesions, the mean percentage of agreement between B-scan detection of cRORA lesions with en face OCT detection was 97.6 % (P = 0.13).

Conclusions: We observed high overall agreement between cRORA lesions identified on B-scans and persistent hyperTDs identified on en face OCT. However, en face imaging was able to detect iRORA lesions that had a greatest linear dimension ≥ 250 μm in a nonhorizontal en face dimension.

Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Keywords: Age-related macular degeneration; Complete retinal pigment epithelial and outer retinal atrophy; En face; Incomplete retinal pigment epithelial and outer retinal atrophy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Atrophy
Cross-Sectional Studies
Fluorescein Angiography
Humans
Retinal Degeneration* / pathology
Retinal Pigment Epithelium* / pathology
Retrospective Studies
Tomography, Optical Coherence / methods