Abstract
A series of (E)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo-[1,5-a]pyrimidine-7-ones were synthesized and evaluated for the inhibition of stress-induced gastric ulcers in the rat after oral administration. Several molecules were found to be very active. The particularly interesting compound (E)-1-(3-chlorophenyl)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo[1,5-a]- pyrimidine-7-one was chosen for wider pharmacological investigation.
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Gastric Juice / metabolism
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Male
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Parasympatholytics
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
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Pyrimidinones / chemical synthesis*
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Pyrimidinones / pharmacology
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / etiology
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Stomach Ulcer / prevention & control*
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Stress, Psychological / complications
Substances
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Anti-Ulcer Agents
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Parasympatholytics
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Pyrazoles
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Pyrimidinones