Clinical efficacy of platelet-rich plasma combined with arthroscopic meniscal plasty on pain, function and physiologic indicators in elderly patients with knee meniscus injury: a retrospective observational study

Xin Yi; Ji Eun Lee; Yun Hwan Lee; Xiaogui Yu; Ho Seong Lee

Clinical efficacy of platelet-rich plasma combined with arthroscopic meniscal plasty on pain, function and physiologic indicators in elderly patients with knee meniscus injury: a retrospective observational study

Am J Transl Res. 2023 Jun 15;15(6):3806-3814. eCollection 2023.

Authors

Xin Yi^{1

2}, Ji Eun Lee^{1

3}, Yun Hwan Lee^{1

3}, Xiaogui Yu⁴, Ho Seong Lee^{1

3}

Affiliations

¹ Department of Exercise and Medical Science, Graduate School, Dankook University Cheonan, South Korea.
² Department of Pain, The First Affiliated Hospital, Hengyang Medical School, University of South China Hengyang, Hunan, China.
³ Institute of Medical-Sports, Dankook University Cheonan, South Korea.
⁴ The First Affiliated Hospital, Operating Room, Hengyang Medical School, University of South China Hengyang, Hunan, China.

PMID: 37434835
PMCID: PMC10331688

Abstract

Objective: To explore the clinical efficacy of platelet-rich plasma (PRP) combined with arthroscopic meniscal plasty on meniscus injury of the knee joint in the elderly.

Methods: Fifty-six elderly patients with meniscus injuries were evaluated, including 28 patients who underwent arthroscopic meniscal repair and 28 patients who underwent arthroscopic meniscus repair combined with PRP injection. Primary outcomes included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lysholm score, Lequesne index, Range of motion (ROM), and secondary outcomes included bone gla-protein (BGP), insulin-like growth factor-1 (IGF-1), and matrix metalloproteinase-1 (MMP-1). The primary and secondary measurement outcomes were assessed for each patient before and after the 12 weeks of treatment.

Results: The VAS, WOMAC, Lysholm, Lequesne, and ROM were more improved in the PRP group compared to the control group (all P < 0.05). BGP, IGF-1, and MMP-1 were more reduced in the PRP group compared to the control group (all P < 0.05).

Conclusion: The treatments of PRP combined with arthroscopic meniscal plasty can significantly improve the pain, function, and physiologicindicators in elderly patients.

Keywords: Platelet-rich plasma; arthroscopic meniscal plasty; knee joint; knee meniscus injury.