The Role of [99mTc]Tc-Sestamibi in Functional Imaging of the Iodine-Loaded Thyroid Gland

J Nucl Med Technol. 2023 Dec 5;51(4):331-332. doi: 10.2967/jnmt.123.265665.

Abstract

Due to high iodine loading from iodinated contrast media, the thyroid uptake of common radiopharmaceuticals ([99mTc]NaTcO4 and [123I]NaI) can be influenced up to 2 mo after administration. In such cases, and generally when differential diagnosis between productive and destructive thyrotoxicosis is necessary, [99mTc]Tc-sestamibi scintigraphy could be an option. This case highlights the role of [99mTc]Tc-sestamibi in the evaluation of thyrotoxicosis in a patient with a blocked thyroid gland as a result of stable iodine saturation.

Keywords: 99mTc-sestamibi; endocrine; iodine saturation; thyroid imaging; thyrotoxicosis.

MeSH terms

  • Humans
  • Iodine*
  • Nitriles
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi
  • Thyrotoxicosis*

Substances

  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi
  • Iodine
  • Organotechnetium Compounds
  • Nitriles