Objective: To observe the clinical efficacy of moxibustion combined with coptis chinensis ointment sealing on plaque psoriasis complicated with obesity.
Methods: A total of 52 patients of plaque psoriasis complicated with obesity were randomized into an observation group (26 cases) and a control group (26 cases, 2 cases dropped off). Coptis chinensis ointment sealing was adopted in the control group. On the basis of the treatment in the control group, moxibustion was applied at ashi point (area of local target lesions), Zhongwan (CV 12) and bilateral Zusanli (ST 36), Fenglong (ST 40), Quchi (LI 11), Tianshu (ST 25), Shangjuxu (ST 37) in the observation group. The treatment was given 30 min each time, once a day for 4 weeks in both groups. The psoriasis area and severity index (PASI) score, obesity related indexes (body mass, waist circumference, body mass index [BMI]), triglyceride, cholesterol, uric acid and plasma glucose were compared before and after treatment, and the clinical efficacy was evaluated in the two groups.
Results: After treatment, the PASI scores were decreased compared with those before treatment in the two groups (P<0.01), and the PASI score in the observation group was lower than that in the control group (P<0.05); the body mass, waist circumference, BMI, triglyceride, cholesterol, uric acid and plasma glucose were decreased compared with those before treatment in the observation group (P<0.01, P<0.05), the triglyceride and cholesterol in the observation group were lower than those in the control group (P<0.05). The total effective rate was 53.8% (14/26) in the observation group, which was superior to 20.8% (5/24) in the control group (P<0.05).
Conclusion: Moxibustion combined with coptis chinensis ointment sealing can effectively improve the clinical symptoms in patients of plaque psoriasis complicated with obesity.
目的：观察艾灸联合黄连膏封包治疗伴有肥胖的斑块型银屑病的临床疗效。方法：将52例伴有肥胖的斑块型银屑病患者随机分为观察组（26例）和对照组（26例，脱落2例）。对照组给予黄连膏封包治疗；在对照组治疗基础上，观察组于阿是穴（局部靶皮损处）、中脘，双侧足三里、丰隆、曲池、天枢、上巨虚行艾灸治疗。两组均每次30 min，每日1次，治疗4周。比较两组患者治疗前后银屑病皮损面积与严重程度指数（PASI）评分、肥胖相关指标[体质量、腰围、体质量指数（BMI）]及三酰甘油、胆固醇、尿酸、血糖，并评定两组临床疗效。结果：治疗后，两组患者PASI评分较治疗前降低（P<0.01），且观察组低于对照组（P<0.05）；观察组患者体质量、腰围、BMI、三酰甘油、胆固醇、尿酸和血糖均较治疗前降低（P<0.01，P<0.05），且三酰甘油、胆固醇低于对照组（P<0.05）。观察组总有效率为53.8%（14/26），高于对照组的20.8%（5/24，P<0.05）。结论：艾灸联合黄连膏封包可改善伴有肥胖的斑块型银屑病患者临床症状。.
Keywords: coptis chinensis ointment; moxibustion; obesity; plaque psoriasis; randomized controlled trial (RCT).