Cationic starch: A functionalized polysaccharide based polymer for advancement of drug delivery and health care system - A review

Int J Biol Macromol. 2023 Sep 1:248:125757. doi: 10.1016/j.ijbiomac.2023.125757. Epub 2023 Jul 8.

Abstract

Research and development in health care industry is in persistence progression. To make it more patient-friendly or to get maximum benefits from it, special attention to different advanced drug delivery system (ADDS) is employed that delivers the drug at the target site and will be able to sustain/control release of drugs. ADDS should be non-toxic, biodegradable, biocompatible along with desirable showing physicochemical and functional properties. These drug delivery systems can be totally based on polymers, either with natural or synthetic polymers. The molecular weight of polymer can be tuned and different groups of polymers can be modified or substituted with other functional groups. Degree of substitution is also tailored. Cationic starch in recent years is exploited in drug delivery, tissue engineering and biomedicine. Due to their abundant availability, low cost, easy chemical modification, low toxicity, biodegradability and biocompatibility, extensive research is now being carried out. Our present discussion will shed light on the usage of cationic starch in health care system.

Keywords: Advanced drug delivery system; Biocompatibility; Biodegradability; Cationic starch; Health care system.

Publication types

  • Review

MeSH terms

  • Cations / chemistry
  • Delivery of Health Care
  • Drug Delivery Systems
  • Humans
  • Polymers* / chemistry
  • Polysaccharides / chemistry
  • Starch* / chemistry

Substances

  • Starch
  • Polymers
  • Polysaccharides
  • Cations