Unusual presentation of uterine tumors resembling ovarian sex cord tumor: A rare case report of cervical involvement

Ghada Sahraoui; Farah Sassi; Lamia Charfi; Feriel Ltaief; Raoudha Doghri; Karima Mrad

doi:10.1016/j.ijscr.2023.108477

Unusual presentation of uterine tumors resembling ovarian sex cord tumor: A rare case report of cervical involvement

Int J Surg Case Rep. 2023 Jul:108:108477. doi: 10.1016/j.ijscr.2023.108477. Epub 2023 Jul 7.

Authors

Ghada Sahraoui¹, Farah Sassi², Lamia Charfi¹, Feriel Ltaief³, Raoudha Doghri¹, Karima Mrad¹

Affiliations

¹ Pathology department, Salah Azaiez Institute, Tunis, Tunisia; Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia.
² Pathology department, Salah Azaiez Institute, Tunis, Tunisia; Research Laboratory LR21SP01, Salah Azaiez Institute, Tunis, Tunisia. Electronic address: sassi.farah@outlook.fr.
³ Oncology Department, Salah Azaiez Institute, Tunis, Tunisia.

Abstract

Introduction and importance: Cervical localization of uterine tumor resembling an ovarian sex cord tumor is very rare (UTROSCT) and this is the third case reported in the English literature. Given its rarity, the diagnosis is frequently challenging. Our aim was to discuss pathological characteristics and treatment choices of this rare disease happening in a rare location.

Case presentation: Our case interested a 19-year-old female patient who presented with a lower abdominal pain and irregular menstrual cycles for a duration of two months. Gynecological examination revealed a cervical firm mass. The patient underwent a cervical lumpectomy. Microscopically, the tumor had nested and trabecular/cord patterns. Tumor cells had abundant cytoplasm, ovoid and spindle-shaped nuclei with fine chromatin. Mitoses were < 1/10 HPFs. A delicate vascular network of small capillaries was noted. Immunohistochemical staining showed that tumor cells were positive for Calretinin, AE1/AE3, Desmin, progesteron receptors, SMA and h-caldesmon. Pathological examination concluded to an UTROSCT.

Clinical discussion: UTROSC is a rare tumor with only two cases with cervical involvement reported so far. They have an indolent clinical history and thus require a more cautious and less invasive therapeutic decision. The diagnosis remains on the pathological examination.

Conclusion: This case is original by its location and the age of presentation. Careful follow-up is necessary searching for local recurrence or metastasis.

Keywords: Cervical cancer; Immunohistochemistry; Pathology; Uterine tumor resembling an ovarian sex cord tumor (UTROSCT).

Publication types

Case Reports