Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures

Homa Rezaei; Elaheh Rahimpour; Fleming Martinez; Abolghasem Jouyban

doi:10.1016/j.heliyon.2023.e17402

Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures

Heliyon. 2023 Jun 19;9(6):e17402. doi: 10.1016/j.heliyon.2023.e17402. eCollection 2023 Jun.

Authors

Homa Rezaei^{1

2}, Elaheh Rahimpour^{2

3}, Fleming Martinez⁴, Abolghasem Jouyban^{2

5}

Affiliations

¹ Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
² Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Universidad Nacional de Colombia, Sede Bogotá, Cra. 30 No. 45-03, Bogotá D. C., Colombia.
⁵ Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van't Hoff and Gibbs equation.

Keywords: Binary solvent mixtures; Cosolvency models; Deferiprone; Thermodynamics; solubility.