Molecularly imprinted ultrasensitive cholesterol photoelectrochemical sensor based on perfluorinated organics functionalization and hollow carbon spheres anchored organic-inorganic perovskite

Liangyun Yu; Yingzhuo Shen; Lu Chen; Qi Zhang; Xiaoya Hu; Qin Xu

doi:10.1016/j.bios.2023.115496

Molecularly imprinted ultrasensitive cholesterol photoelectrochemical sensor based on perfluorinated organics functionalization and hollow carbon spheres anchored organic-inorganic perovskite

Biosens Bioelectron. 2023 Oct 1:237:115496. doi: 10.1016/j.bios.2023.115496. Epub 2023 Jun 23.

Authors

Liangyun Yu¹, Yingzhuo Shen², Lu Chen², Qi Zhang³, Xiaoya Hu⁴, Qin Xu⁵

Affiliations

¹ School of Light Industry, Beijing Technology and Business University, No. 11 Fucheng Road, Haidian District, Beijing, 100048, PR China.
² College of Chemistry and Engineering, Yangzhou University, Yangzhou, 225002, PR China.
³ School of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng, 224051, PR China.
⁴ College of Chemistry and Engineering, Yangzhou University, Yangzhou, 225002, PR China. Electronic address: xyhu@yzu.edu.cn.
⁵ College of Chemistry and Engineering, Yangzhou University, Yangzhou, 225002, PR China. Electronic address: xuqin@yzu.edu.cn.

PMID: 37421798
DOI: 10.1016/j.bios.2023.115496

Abstract

In spite of organic-inorganic perovskite emerging as a novel efficient light-harvesting material owing to their superior optical properties, excitonic properties, and electrical conductivity, the related applications are severely limited for their poor stability and selectivity. Herein, we introduced hollow carbon spheres (HCSs) and 2-(perfluorohexyl) ethyl methacrylate (PFEM) based molecularly imprinted polymers (MIPs) to dual-functionalize CH₃NH₃PbI₃. HCSs can provide perovskite load conditions, passivate perovskite defects, increase carrier transport and effectively improve its hydrophobicity. The perfluorinated organic compound based MIPs film can not only enhance the water and oxygen stability of perovskite, but also endow it specific selectivity. Moreover, it can reduce the photoexcited electron-hole pair recombination and prolong the electron lifetime. Benefiting from the synergistic sensitization of HCSs and MIPs, an ultrasensitive photoelectrochemical platform (MIPs@CH₃NH₃PbI₃@HCSs/ITO) for cholesterol sensing was acquired with a very wide linear range of 5.0 × 10^-14-5.0 × 10^-8 mol/L and an extremely low detection limit of 2.39 × 10^-15 mol/L. The designed PEC sensor exhibited good selectivity and stability, as well as practicality for real sample analysis. The present work extended the development of the high-performance perovskite and showed its broad application prospect for advanced PEC construction.

Keywords: CH(3)NH(3)PbI(3); Cholesterol; Hollow carbon spheres; Molecularly imprinted polymer; Photoelectrochemical sensor.

MeSH terms

Biosensing Techniques* / methods
Carbon / chemistry
Electrochemical Techniques / methods
Molecular Imprinting* / methods

Substances

perovskite
Carbon