Go along to get along: Integrator at active replication forks defuses co-directional transcription-replication conflicts

Leticia Dinatto; Peter C Stirling

doi:10.1016/j.molcel.2023.06.005

Go along to get along: Integrator at active replication forks defuses co-directional transcription-replication conflicts

Mol Cell. 2023 Jul 6;83(13):2161-2163. doi: 10.1016/j.molcel.2023.06.005.

Authors

Leticia Dinatto¹, Peter C Stirling²

Affiliations

¹ Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
² Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. Electronic address: pstirling@bccrc.ca.

PMID: 37419089
DOI: 10.1016/j.molcel.2023.06.005

Abstract

There has been growing appreciation that transcription is an endogenous source of replication stress and must be coordinated with replication. In this issue, Bhowmick et al.¹ uncover a protective mechanism that prevents co-directional transcription-replication conflicts (TRCs) from becoming genotoxic.

MeSH terms

DNA Damage
DNA Replication*
Transcription, Genetic*