Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation

Roland Hjerpe; Thimo Kurz

doi:10.1016/j.molcel.2023.06.017

Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation

Mol Cell. 2023 Jul 6;83(13):2159-2160. doi: 10.1016/j.molcel.2023.06.017.

Authors

Roland Hjerpe¹, Thimo Kurz²

Affiliations

¹ Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham NG1 1GR, UK.
² School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, UK; Evotec SE, Innovation Dr, Milton, Abingdon OX14 4RT, UK. Electronic address: thimo.kurz@glasgow.ac.uk.

PMID: 37419088
DOI: 10.1016/j.molcel.2023.06.017

Abstract

Most methods for targeted protein degradation (TPD) deliver targets to E3 ubiquitin ligases, leading to proteasomal degradation. In this issue of Molecular Cell, Shaaban et al.¹ illuminate cullin-RING ubiquitin ligase (CRL) modulation by CAND1, which can be utilized for TPD.

MeSH terms

Cryoelectron Microscopy
Cullin Proteins* / genetics
Cullin Proteins* / metabolism
Proteolysis
Ubiquitin / metabolism
Ubiquitin-Protein Ligases* / genetics
Ubiquitin-Protein Ligases* / metabolism

Substances

Cullin Proteins
Ubiquitin-Protein Ligases
Ubiquitin