TRAPPIII requires Drs2 binding to transport Atg9 vesicles at cold temperatures

Autophagy. 2023 Nov;19(11):3017-3018. doi: 10.1080/15548627.2023.2233365. Epub 2023 Jul 6.

Abstract

Autophagy-related 9 (Atg9); cytoplasm-to-vacuole targeting (Cvt); Golgi-associated retrograde protein (GARP); multisubunit tethering complexes (MTCs); phagophore assembly site (PAS); phosphatidylserine (PS); Protein interactions from Imaging Complexes after Translocation (PICT); transport protein particle III (TRAPPIII); type IV P-type ATPases (P4-ATPases).

Keywords: Atg9; Drs2; P4-ATPases; TRAPPIII; cytoplasm-to-vacuole targeting; multisubunit tethering complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autophagy
  • Autophagy-Related Proteins / metabolism
  • Cold Temperature
  • Protein Transport
  • Saccharomyces cerevisiae Proteins* / metabolism
  • Transport Vesicles / metabolism
  • Vesicular Transport Proteins* / metabolism

Substances

  • Autophagy-Related Proteins
  • Saccharomyces cerevisiae Proteins
  • Vesicular Transport Proteins
  • DRS2 protein, S cerevisiae

Grants and funding

The work was supported by the Agencia Estatal de Investigación [PID2021-127773NB-I00, MDM-2014-0370]; Human Frontier Science Program [RGP0017/2020].