The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care

Abstract

Background: Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet the optimal approach remains uncertain. Whilst some data on the metabolic response to whole body exercise in critical care exist, the metabolic response to IMT in critical care is yet to be investigated. This study aimed to quantify the metabolic response to IMT in critical care and its relationship to physiological variables.

Methods: We conducted a prospective observational study on mechanically ventilated patients ventilated for ≥ 72 h and able to participate in IMT in a medical, surgical, and cardiothoracic intensive care unit. 76 measurements were taken on 26 patients performing IMT using an inspiratory threshold loading device at 4 cmH₂O, and at 30, 50 and 80% of their negative inspiratory force (NIF). Oxygen consumption (VO₂) was measured continuously using indirect calorimetry.

Results: First session mean (SD) VO₂ was 276 (86) ml/min at baseline, significantly increasing to 321 (93) ml/min, 333 (92) ml/min, 351(101) ml/min and 388 (98) ml/min after IMT at 4 cmH₂O and 30, 50 and 80% NIF, respectively (p = 0.003). Post hoc comparisons revealed significant differences in VO₂ between baseline and 50% NIF and baseline and 80% NIF (p = 0.048 and p = 0.001, respectively). VO₂ increased by 9.3 ml/min for every 1 cmH₂O increase in inspiratory load from IMT. Every increase in P/F ratio of 1 decreased the intercept VO₂ by 0.41 ml/min (CI - 0.58 to - 0.24 p < 0.001). NIF had a significant effect on the intercept and slope, with every 1 cmH₂O increase in NIF increasing intercept VO₂ by 3.28 ml/min (CI 1.98-4.59 p < 0.001) and decreasing the dose-response slope by 0.15 ml/min/cmH₂O (CI - 0.24 to - 0.05 p = 0.002).

Conclusions: IMT causes a significant load-dependent increase in VO₂. P/F ratio and NIF impact baseline VO₂. The dose-response relationship of the applied respiratory load during IMT is modulated by respiratory strength. These data may offer a novel approach to prescription of IMT.

Take home message: The optimal approach to IMT in ICU is uncertain; we measured VO₂ at different applied respiratory loads to assess whether VO₂ increased proportionally with load and found VO₂ increased by 9.3 ml/min for every 1 cmH₂O increase in inspiratory load from IMT. Baseline NIF has a significant effect on the intercept and slope, participants with a higher baseline NIF have a higher resting VO₂ but a less pronounced increase in VO₂ as the inspiratory load increases; this may offer a novel approach to IMT prescription. Trial registration ClinicalTrials.gov, registration number: NCT05101850. Registered on 28 September 2021, https://clinicaltrials.gov/ct2/show/NCT05101850.

Keywords: Artificial; Critical care; Oxygen consumption; Physical therapy modalities; Rehabilitation; Respiration.