Amyloid-like protein bridged nano-materials and fabrics for preparing rapid and long lasting antibacterial, UV-resistant and personal thermal management textiles

Int J Biol Macromol. 2023 Aug 30:247:125699. doi: 10.1016/j.ijbiomac.2023.125699. Epub 2023 Jul 5.

Abstract

Textiles with efficient and long-lasting antibacterial properties have attracted significant attention. However, a single antibacterial model is insufficient to with variable environments and achieve higher antibacterial activity. In this study, lysozyme was used as assistant and stabilizer, and the efficient peeling and functional modification of molybdenum disulfide nanosheets were realized by ultrasonic. Additionally, lysozyme in the presence of reducing agents to form amyloid-like phase-transited lysozyme (PTL) and self-assembling on the wool fabric. Finally, the AgNPs are reduced in situ by PTL and anchored onto the fabric. It has been demonstrated that Ag-MoS2/PTL@wool generates ROS under light irradiation, rapidly converts photothermal heat into generate hyperthermia, and promotes the release of Ag+. The aforementioned "four-in-one" approach resulted in bactericidal rates of 99.996 % (4.4 log, P < 0.0005) and 99.998 % (4.7 log, P < 0.0005) for S.aureus and E.coli, respectively. Even after 50 washing cycles, the inactivation rates remained at 99.813 % and 99.792 % for E.coli and S.aureus, respectively. In the absence of sunlight, AgNPs and PTL continue to provide continuous antibacterial activity. This work emphasizes the importance of amyloid protein in the synthesis and application of high-performance nanomaterials and provides a new direction for the safe and effective application of multiple synergistic antibacterial modes for microbial inactivation.

Keywords: Antibacterial strategy; Personal thermal management; Phase-transited lysozyme.

MeSH terms

  • Amyloidogenic Proteins*
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Muramidase*
  • Textiles
  • Wool

Substances

  • Muramidase
  • Amyloidogenic Proteins
  • Anti-Bacterial Agents