Benefits of fermented synbiotic soymilk containing Lactobacillus acidophilus, Bifidobacterium lactis, and inulin towards lead toxicity alleviation

Maryamsadat Riasatian; Seyed Mohammad Mazloomi; Afsane Ahmadi; Zahra Derakhshan; Saeed Rajabi

doi:10.1016/j.heliyon.2023.e17518

Benefits of fermented synbiotic soymilk containing Lactobacillus acidophilus, Bifidobacterium lactis, and inulin towards lead toxicity alleviation

Heliyon. 2023 Jun 23;9(6):e17518. doi: 10.1016/j.heliyon.2023.e17518. eCollection 2023 Jun.

Authors

Maryamsadat Riasatian¹, Seyed Mohammad Mazloomi², Afsane Ahmadi², Zahra Derakhshan^{3

4}, Saeed Rajabi^{4

5}

Affiliations

¹ Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
² Nutrition Research Center, School of Nutrition and Food Sciences, Department of Clinical Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Research Center for Health Sciences, Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ Department of Environmental Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
⁵ Student Research Committee, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

This study aims to evaluate the effect of fermented synbiotic soy milk containing Lactobacillus acidophilus, Bifidobacterium lactis, and inulin on a series of hematological and oxidative stress parameters, as well as serum lead levels in rats. In this study, 56 male Sprague-Dawley rats were randomly assigned to assess probiotics (L. acidophilus or B. lactis), probiotics with prebiotics (i.e., inulin), and the corresponding controls. Several hematologic parameters (red blood cell (RBC)), hematocrit (HCT) and hemoglobin (Hgb)), serum lead levels, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) presence was measured to evaluate changes on day 42. Although a significant difference was observed in serum lead levels, there were no significant changes in hematological and oxidative stress parameters between the study groups. In conclusion, this study demonstrates that administering synbiotic fermented soy milk containing the probiotic Lactobacillus acidophilus and the prebiotic inulin may significantly improve serum lead levels in rats.

Keywords: Lead; Oxidative stress; Prebiotic; Probiotic bacteria; Soybean milk.