[Epoxy ring scission in the oleandomycin molecule during aging]

Antibiot Med Biotekhnol. 1986 Jun;31(6):434-6.
[Article in Russian]

Abstract

Opening of the epoxide ring in the molecule of oleandomycin phosphate in the process of its aging was shown to be possible by the data of the analysis. Certain correlation between the "glycol" content and drug activity was detected.

Publication types

  • English Abstract

MeSH terms

  • Drug Stability
  • Drug Storage
  • Epoxy Compounds*
  • Ethers, Cyclic*
  • Molecular Conformation
  • Oleandomycin / analysis
  • Oleandomycin / pharmacology*
  • Structure-Activity Relationship
  • Temperature

Substances

  • Epoxy Compounds
  • Ethers, Cyclic
  • Oleandomycin