In 2016, Wales became the first country in the world to appoint a Future Generations Commissioner - in essence a 'guardian' of the interests of future generations - under its Well-being Future Generations (Wales) Act 2015. The Act puts in place seven long-term wellbeing goals: a prosperous Wales; a resilient Wales; a more equal Wales; a healthier Wales; a Wales of cohesive communities; a Wales of vibrant culture & thriving Welsh language; and a globally responsible Wales. The Act also defines five 'ways of working' or principles that public bodies must demonstrate in decision making: thinking for the long-term, prevention; integration; collaboration; and involvement. The inaugural Commissioner, Sophie Howe, who held the role for seven years, reflects on the challenges and successes of leading transformational change to achieve a whole-of-government focus on wellbeing across policy and practice. In this interview with PHRP Editor-in-Chief Don Nutbeam, she shares some of the key lessons learned during her time in the role, including the need to embed the future generations approach in law, to set holistic, long-term goals - and to avoid blindly following measures and metrics.