Capillary carbon dioxide tension increases in hospital staff wearing filtering facepiece masks: a prospective crossover study

Georg Roeder; Aylin Bilir; Alexandra Graf; David M Baron

doi:10.1183/23120541.00186-2023

Capillary carbon dioxide tension increases in hospital staff wearing filtering facepiece masks: a prospective crossover study

ERJ Open Res. 2023 Jul 3;9(4):00186-2023. doi: 10.1183/23120541.00186-2023. eCollection 2023 Jul.

Authors

Georg Roeder¹, Aylin Bilir¹, Alexandra Graf², David M Baron¹

Affiliations

¹ Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria.
² Center for Medical Data Science, Institute of Medical Statistics, Medical University Vienna, Vienna, Austria.

Abstract

Background: The COVID-19 pandemic has changed worldwide hygiene practices. In particular, the use of filtering face piece (FFP) masks markedly increased. Concerns have been raised regarding possible negative respiratory effects of wearing FFP masks. The aim of this study was to investigate gas exchange and subjective breathing effort in hospital personnel wearing FFP2 or FFP3 masks.

Methods: In this prospective, single-centre, crossover study, 200 hospital workers were assigned to alternately wear FFP2 or FFP3 masks for 1 h during routine activities. Capillary blood gas analysis was performed to evaluate gas exchange while wearing the FFP masks. The primary end-point was the change in capillary partial pressure of carbon dioxide (P_cCO₂). In addition, capillary partial pressure of oxygen (P_cO₂), respiratory rate and subjective breathing effort were assessed at the end of each hour. Changes between time points and study groups were estimated using univariate and multivariate models.

Results: P_cCO₂ increased from 36.8±3.5 to 37.2±3.3 mmHg (p=0.047) and 37.4±3.2 mmHg (p=0.003) in individuals wearing FFP2 or FFP3 masks, respectively. Age (p=0.021) and male sex (p<0.001) were significantly associated with increased P_cCO₂. Similarly, the P_cO₂ increased from 70.7±8.4 to 73.4±8.8 mmHg (p<0.001) and 72.8±8.5 mmHg (p=0.004) in individuals wearing FFP2 or FFP3 masks, respectively. Respiratory rate and subjective breathing effort increased significantly while wearing FFP2 and FFP3 masks (p<0.001 for all analyses). The order of wearing FFP2 or FFP3 masks did not significantly affect the results.

Conclusions: An hour of wearing FFP2 or FFP3 masks increased P_cCO₂ values, respiratory rate and subjective breathing effort in healthcare personnel performing routine activities.