Five new sesquiterpenoids from agarwood of Aquilaria sinensis

Hong Zhou; Xu-Yang Li; Hong-Bin Fang; He-Zhong Jiang; Yong-Xian Cheng

doi:10.3762/bjoc.19.75

Five new sesquiterpenoids from agarwood of Aquilaria sinensis

Beilstein J Org Chem. 2023 Jun 30:19:998-1007. doi: 10.3762/bjoc.19.75. eCollection 2023.

Authors

Hong Zhou¹, Xu-Yang Li², Hong-Bin Fang², He-Zhong Jiang¹, Yong-Xian Cheng^{1

2}

Affiliations

¹ School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.
² Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China.

Abstract

Five new eudesmane-type sesquiterpenoids (aquisinenoids F-J (1-5)) and five known compounds (6-10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure-activity relationships (SAR).

Keywords: Aquilaria sinensis; SAR studies; agarwood; sesquiterpenoids.

Grants and funding

This study was supported by the Shenzhen Fundamental Research Program (JCYJ20200109114003921) and National Science Fund for Distinguished Young Scholars (81525026).