The sesquiterpenes with the COVID-19 Mpro inhibitory activity from the Carpesium abrotanoides L

Yu-Wen Fan; Zhuo-Yi Ao; Wei-Jie Zhang; Jia-Yan Chen; Xin Lian; Yong- Chen Pan; Li-Ping Chen; Jie-Wei Wu; Jie Yuan

doi:10.1080/14786419.2023.2230609

The sesquiterpenes with the COVID-19 M^pro inhibitory activity from the Carpesium abrotanoides L

Nat Prod Res. 2023 Jul 5:1-9. doi: 10.1080/14786419.2023.2230609. Online ahead of print.

Authors

Yu-Wen Fan¹, Zhuo-Yi Ao¹, Wei-Jie Zhang¹, Jia-Yan Chen¹, Xin Lian¹, Yong- Chen Pan¹, Li-Ping Chen¹, Jie-Wei Wu¹, Jie Yuan¹

Affiliation

¹ School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

PMID: 37403616
DOI: 10.1080/14786419.2023.2230609

Abstract

The extract of the whole plant of Carpesium abrotanoides L. yielded four new sesquiterpenes including a novel skeleton (claroguaiane A, 1), two guaianolides (claroguaianes B-C, 2-3), and one eudesmanolide (claroeudesmane A, 4), together with three known sesquiterpenoids (5-7). The structures of the new compounds were elucidated by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitive activity of COVID-19 M^pro. As a result, compound 5 showed moderate activity with an IC₅₀ value of 36.81 μM and compound 6 exhibited a potent inhibitory effect with an IC₅₀ value of 16.58 µM, while other compounds were devoid of noticeable activity (IC₅₀ > 50 μM).

Keywords: COVID-19 Mpro; Carpesium abrotanoides L.; Sesquiterpenes; inhibitory activity; structure elucidation.