Synthetic Light-Driven Consortia for Carbon-Negative Biosynthesis

Chaofeng Li; Haotian Zheng; Hengrun Li; Liangxu Liu; Jiawei Wang; Jun Ni

doi:10.1002/cbic.202300122

Synthetic Light-Driven Consortia for Carbon-Negative Biosynthesis

Chembiochem. 2023 Sep 1;24(17):e202300122. doi: 10.1002/cbic.202300122. Epub 2023 Aug 3.

Authors

Chaofeng Li^{1

2}, Haotian Zheng^{1

2}, Hengrun Li^{1

2}, Liangxu Liu^{1

2}, Jiawei Wang^{1

2}, Jun Ni^{1

2}

Affiliations

¹ State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
² Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, China.

PMID: 37401840
DOI: 10.1002/cbic.202300122

Abstract

Synthetic light-driven consortia composed of phototrophs and heterotrophs have attracted increasing attention owing to their potential to be used in sustainable biotechnology. In recent years, synthetic phototrophic consortia have been used to produce bulk chemicals, biofuels, and other valuable bioproducts. In addition, autotrophic-heterotrophic symbiosis systems have potential applications in wastewater treatment, bioremediation, and as a method for phytoplankton bloom control. Here, we discuss progress made on the biosynthesis of phototrophic microbial consortia. In addition, strategies for optimizing the synthetic light-driven consortia are summarized. Moreover, we highlight current challenges and future research directions for the development of robust and controllable synthetic light-driven consortia.

Keywords: carbon-negative biosynthesis; cyanobacteria; quorum sensing; rational modelling; synthetic light-driven consortia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biodegradation, Environmental
Biotechnology* / methods
Microbial Consortia*
Symbiosis
Synthetic Biology / methods