Primary pulmonary lymphoma in Peru

Elily Dianet Apumayta Requena; Danery Valdez Ocrospoma; Jhonatanael Salvador Ruiz; Alberto De la Guerra Pancorvo; Edgar Amorin Kajatt

doi:10.3332/ecancer.2023.1559

Primary pulmonary lymphoma in Peru

Ecancermedicalscience. 2023 Jun 15:17:1559. doi: 10.3332/ecancer.2023.1559. eCollection 2023.

Authors

Elily Dianet Apumayta Requena^{1

2}, Danery Valdez Ocrospoma^{3

4}, Jhonatanael Salvador Ruiz^{5

6}, Alberto De la Guerra Pancorvo⁷, Edgar Amorin Kajatt⁷

Affiliations

¹ Surgical Oncology Resident, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
² https://orcid.org/0000-0002-1828-7009.
³ Oncological Pathology Fellow, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
⁴ https://orcid.org/0000-0002-7872-7950.
⁵ Medical Student, San Martin de Porres University, Lima, Perú.
⁶ https://orcid.org/0000-0002-2399-957X.
⁷ Thoracic Surgical Oncology Unit, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.

Abstract

Objective: To describe the clinical features, imaging, pathology and management of patients with primary pulmonary lymphoma (PPL).

Methodology: This is a case series study involving a retrospective analysis of 24 patients diagnosed with PPL between the years 2000-2019 at Instituto Nacional de Enfermedades Neoplásicas in Lima, Perú.

Results: 73.9% of patients were male. Cough (78.3%) and weight loss (56.5%) were the most frequent clinical features. Dyspnoea and elevated values of DHL and B2 microglobulin were frequently altered in advanced stages. Diffuse large B cell lymphoma (DLBCL) represented 47.8% of the cases and the most common radiologic alterations were a mass (60%) and consolidation with air bronchogram (60%). The most utilised treatment was chemotherapy alone (60%). Three patients received only surgery. Median survival was 30 months. Five overall survival was 45%, and up to 60% in the case of mucosa-associated lymphoid tissue lymphoma.

Conclusion: PPL is infrequent. Clinical features are unspecific and the principal finding is a mass, nodule or consolidation with air bronchogram. Definitive diagnosis needs biopsy and immunohistochemistry. There is no standard treatment, it depends on histology type and stage.

Keywords: lung neoplasms; lymphoma; primary lung lymphoma.