N-Fluorobenzenesulfonimide (NFSI) analogs with deprotectable substituents: synthesis of β-fluoroamines via catalytic aminofluorination of styrenes

Yuki Ito; Akiya Adachi; Kohsuke Aikawa; Kyoko Nozaki; Takashi Okazoe

doi:10.1039/d3cc02292g

N-Fluorobenzenesulfonimide (NFSI) analogs with deprotectable substituents: synthesis of β-fluoroamines via catalytic aminofluorination of styrenes

Chem Commun (Camb). 2023 Jul 25;59(60):9195-9198. doi: 10.1039/d3cc02292g.

Authors

Yuki Ito¹, Akiya Adachi¹, Kohsuke Aikawa¹, Kyoko Nozaki², Takashi Okazoe^{1

3}

Affiliations

¹ Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan. aikawa@g.ecc.u-tokyo.ac.jp.
² Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
³ Yokohama Technical Center, AGC Inc., 1-1 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

PMID: 37395551
DOI: 10.1039/d3cc02292g

Abstract

The palladium-catalyzed aminofluorination of styrenes using novel N-fluorobenzenesulfonimide (NFSI) derivatives with deprotectable substituents, and the selective deprotection and transformation of the resulting products into amines under mild reaction conditions are herein disclosed.