Spondyloarthritides

Immunol Allergy Clin North Am. 2023 Aug;43(3):593-612. doi: 10.1016/j.iac.2022.10.001.

Abstract

The spondyloarthritides are a diverse group of distinct yet interrelated disease processes with overlapping clinical features. They are ankylosing spondylitis, reactive arthritis, inflammatory bowel disease-associated arthritis, and psoriatic arthritis. Genetically, these disease processes have been linked by the presence of HLA-B27. They manifest with axial and peripheral symptoms, such as inflammatory back pain, enthesitis, oligoarthritis, and dactylitis. The onset of symptoms can begin before the age of 45; however, because of the wide range of signs and symptoms, diagnosis can be delayed, leading to unchecked inflammation, structural damage, and later, restriction in physical mobility.

Keywords: Ankylosing spondylitis; Axial spondylitis; Inflammatory bowel disease–associated spondyloarthritis; Psoriatic arthritis; Reactive arthritis; Spondyloarthritides.

Publication types

  • Review

MeSH terms

  • Arthritis, Psoriatic* / diagnosis
  • Arthritis, Reactive* / diagnosis
  • Humans
  • Inflammatory Bowel Diseases* / diagnosis
  • Inflammatory Bowel Diseases* / etiology
  • Spondylarthritis* / diagnosis
  • Spondylarthritis* / etiology
  • Spondylitis, Ankylosing* / diagnosis
  • Spondylitis, Ankylosing* / etiology