Antidepressant-like effects of L-menthol mediated by alleviating neuroinflammation and upregulating the BDNF/TrkB signaling pathway in subchronically lipopolysaccharide-exposed mice

Brain Res. 2023 Oct 1:1816:148472. doi: 10.1016/j.brainres.2023.148472. Epub 2023 Jun 29.

Authors

Shuai-Ming Zhu¹, Rui Xue², Yi-Fei Chen³, Yang Zhang², Jun Du³, Fu-Yao Luo², Hao Ma², Yu Yang², Rui Xu², Jing-Cao Li², Shuo Li², Chang-Wei Li², Xiang Gao², You-Zhi Zhang⁴

Affiliations

¹ Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
² Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
³ Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
⁴ Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: bcczyz@163.com.

PMID: 37393011
DOI: 10.1016/j.brainres.2023.148472

No abstract available

Keywords: Antidepressant-like effects; BDNF/TrkB signaling pathway; L-menthol; Lipopolysaccharide-induced; Neuroinflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents / metabolism
Antidepressive Agents / pharmacology
Brain-Derived Neurotrophic Factor* / metabolism
Hippocampus / metabolism
Lipopolysaccharides* / metabolism
Lipopolysaccharides* / pharmacology
Menthol / pharmacology
Mice
Neuroinflammatory Diseases
Receptor, trkB / metabolism
Signal Transduction

Substances

Brain-Derived Neurotrophic Factor
Lipopolysaccharides
Menthol
Antidepressive Agents
Receptor, trkB