Towards new antibiotics classes targeting bacterial metallophores

Zeinab Ezzeddine; Ghassan Ghssein

doi:10.1016/j.micpath.2023.106221

Towards new antibiotics classes targeting bacterial metallophores

Microb Pathog. 2023 Sep:182:106221. doi: 10.1016/j.micpath.2023.106221. Epub 2023 Jun 29.

Authors

Zeinab Ezzeddine¹, Ghassan Ghssein²

Affiliations

¹ Laboratory Sciences Department, Faculty of Public Health, Islamic University of Lebanon (IUL), Khalde P.O. Box, 30014, Lebanon; Faculty of Sciences V, Lebanese University, Nabatieh, 1700, Lebanon. Electronic address: zeinabezzeddine.87@hotmail.com.
² Laboratory Sciences Department, Faculty of Public Health, Islamic University of Lebanon (IUL), Khalde P.O. Box, 30014, Lebanon; Faculty of Sciences V, Lebanese University, Nabatieh, 1700, Lebanon. Electronic address: ghassan.ghssein@iul.edu.lb.

PMID: 37391099
DOI: 10.1016/j.micpath.2023.106221

Abstract

The increasing bacterial resistance caused by antibiotic overuse has promoted the search for new antimicrobial strategies. Metals uptake via bacterial metallophores are studied to develop new therapeutics against infectious diseases, because metal ions are essential for bacterial growth and virulence. Metal ions assimilation is mainly dependent on metallophores production which are metal chelators synthetized and produced by bacteria to facilitate metals uptake and are vital for bacterial pathogenicity. Here we highlight the perspective for antimicrobial and therapeutic potential of metallophores through several approaches for metallophores application in antimicrobial therapy.

Keywords: Antimicrobial therapy; Bacterial resistance; Infectious diseases; Metallophores.

Publication types

Editorial

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Infective Agents*
Bacteria
Ions
Metals

Substances

Anti-Bacterial Agents
Metals
Anti-Infective Agents
Ions