The multifunction of HSP70 in cancer: Guardian or traitor to the survival of tumor cells and the next potential therapeutic target

Gengyu Sha; Zhengting Jiang; Wenjie Zhang; Chuwen Jiang; Daorong Wang; Dong Tang

doi:10.1016/j.intimp.2023.110492

The multifunction of HSP70 in cancer: Guardian or traitor to the survival of tumor cells and the next potential therapeutic target

Int Immunopharmacol. 2023 Sep:122:110492. doi: 10.1016/j.intimp.2023.110492. Epub 2023 Jun 28.

Authors

Gengyu Sha¹, Zhengting Jiang², Wenjie Zhang³, Chuwen Jiang⁴, Daorong Wang⁵, Dong Tang⁶

Affiliations

¹ Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225000, China. Electronic address: 192201611@stu.yzu.edu.cn.
² Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225000, China. Electronic address: 192201607@stu.yzu.edu.cn.
³ Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225000, China. Electronic address: 182201636@stu.yzu.edu.cn.
⁴ Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225000, China. Electronic address: 757818029@qq.com.
⁵ Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou 225000, China. Electronic address: 192201601@stu.yzu.edu.cn.
⁶ Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou 225000, China. Electronic address: 18952783556@yzu.edu.cn.

PMID: 37390645
DOI: 10.1016/j.intimp.2023.110492

Abstract

Heat shock protein 70 (HSP70) is a highly conserved protein composed of nucleotide-binding domains (NBD) and C-terminal substrate binding domain (SBD) that can function as a "molecular chaperone". HSP70 was discovered to directly or indirectly play a regulatory role in both internal and external apoptosis pathways. Studies have shown that HSP70 can not only promote tumor progression, enhance tumor cell resistance and inhibit anticancer effects but also induce an anticancer response by activating immune cells. In addition, chemotherapy, radiotherapy and immunotherapy for cancer may be affected by HSP70, which has shown promising potential as an anticancer drug. In this review, we summarized the molecular structure and mechanism of HSP70 and discussed the dual effects of HSP70 on tumor cells and the possibility and potential methods of using HSP70 as a target to treat cancer.

Keywords: Cancer; HSP70; Immunological therapy; Versatility.

Publication types

Review

MeSH terms

HSP70 Heat-Shock Proteins* / metabolism
Humans
Immunotherapy
Molecular Chaperones / metabolism
Neoplasms* / drug therapy
Protein Binding

Substances

HSP70 Heat-Shock Proteins
Molecular Chaperones