Implementation and evaluation of ultra-low dose CT in early cystic fibrosis lung disease

Katie J Bayfield; Oliver Weinheimer; Christie Boyton; Rachel Fitzpatrick; Anna Middleton; Brendan Kennedy; Anneliese Blaxland; Geshani Jayasuriya; Neil Caplain; Hana Issa; Robert Goetti; Mark O Wielpütz; Lifeng Yu; Craig J Galban; Terry E Robinson; Brian Bartholmai; Dominic Fitzgerald; Hiran Selvadurai; Paul D Robinson

doi:10.1183/13993003.00286-2023

Implementation and evaluation of ultra-low dose CT in early cystic fibrosis lung disease

Eur Respir J. 2023 Jul 7;62(1):2300286. doi: 10.1183/13993003.00286-2023. Print 2023 Jul.

Authors

Katie J Bayfield^{1

2}, Oliver Weinheimer^{3

4

2}, Christie Boyton¹, Rachel Fitzpatrick¹, Anna Middleton¹, Brendan Kennedy¹, Anneliese Blaxland¹, Geshani Jayasuriya^{1

5}, Neil Caplain¹, Hana Issa¹, Robert Goetti¹, Mark O Wielpütz^{3

4}, Lifeng Yu⁶, Craig J Galban⁷, Terry E Robinson⁸, Brian Bartholmai⁶, Dominic Fitzgerald^{1

9}, Hiran Selvadurai^{1

9}, Paul D Robinson^{1

5

9}

Affiliations

¹ The Children's Hospital at Westmead, Westmead, Australia.
² Joint first authors.
³ Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
⁴ Translational Lung Research Center Heidelberg, German Center for Lung Research DZL, Heidelberg, Germany.
⁵ Woolcock Institute of Medical Research, Sydney, Australia.
⁶ Division of Radiology, Mayo Clinic Rochester, Rochester, MN, USA.
⁷ Department of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
⁸ Stanford University Medical Centre, Stanford University, Stanford, CA, USA paul.robinson@uq.edu.au.
⁹ The University of Sydney, Sydney, Australia.

Abstract

Early cystic fibrosis lung disease requires urgent sensitive outcome measures. Ultra-low dose CT provides comparable quantitative structural insight into bronchiectasis compared to conventional low dose CT, but higher rates of air trapping. https://bit.ly/3Wi8MLr

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cystic Fibrosis* / diagnostic imaging
Humans
Lung / diagnostic imaging
Tomography, X-Ray Computed

Grants and funding

R01 HL139690/HL/NHLBI NIH HHS/United States